HighQC™ Human (Parental) Breast Cancer Stem Cell

Description

HighQC™ Human (Parental) Breast Cancer Stem Cells are derived from human breast carcinoma tissue and represent a subpopulation of tumor-initiating cells with stem-like properties. These cells exhibit an epithelial morphology and express characteristic markers such as CD44 and CD133.Maintained under serum-free, non-adherent culture conditions, they maintain self-renewal capacity and can recapitulate tumor heterogeneity upon differentiation. Karyotype analysis often reveals chromosomal instability. Morphologically, the cells appear as compact, round-to-oval clusters with a high nuclear-to-cytoplasmic ratio, consistent with an undifferentiated state. Gene expression profiling reveals upregulation of stemness-associated genes such as NANOG, SOX2, and OCT4. They are ideal for studying the molecular pathways underlying breast cancer initiation, progression, metastasis, and resistance to therapy.