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| Product Code | Hk-2; HK2; Human Kidney-2 |
| Species | Human |
| Cat.No | ABC-TC0387 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Kidney |
| Disease | Papilloma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
HK-2 is a proximal tubule epithelial cell line that was originally isolated from normal kidney tissue from an adult male. HK-2 were established and immortalized by transduction with HPV-16 E6/E7 genes via a recombinant retrovirus. These cells exhibit a well-differentiated phenotype characteristic of proximal tubular cells (PTCs), expressing genes like EGF and relying on it for growth and survival. Positive for markers such as alkaline phosphatase, gamma glutamyltranspeptidase, and cytokeratin, as well as integrins and fibronectin, HK-2 cells are distinctively negative for factor VIII related antigen, 6.19 antigen. They retain functional traits of PTCs, including sugar transport sensitivity to phlorizin, adenylate cyclase response to parathyroid hormone, and gluconeogenesis ability demonstrated by glycogen production and storage.
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The HK-2 cell line finds versatile applications, prominently in toxicology research, where its capacity to replicate outcomes from freshly isolated PTCs proves valuable. Its utility extends to investigating the impacts of environmental toxins like cadmium and cisplatin on kidney cells, as well as delving into the mechanisms underlying kidney disorders like diabetic nephropathy and acute kidney injury. Moreover, the line is instrumental in 3D cell culture and high-throughput screening approaches, highlighting its significance across multiple research avenues.
