Human Epidermal Keratinocytes, Adult

Description

Human Epidermal Keratinocytes are primary epithelial cells isolated from adult human skin and cryopreserved following initial culture. These cells exhibit polygonal morphology and adherent growth and are primarily located in the basal and suprabasal layers of the epidermis. They express key keratinocyte markers such as keratin 5 (KRT5) and keratin 14 (KRT14), which play crucial roles in regulating proliferation and differentiation. Human Epidermal Keratinocytes are essential for forming and maintaining the skin’s protective barrier and actively respond to environmental challenges such as UV radiation, oxidative stress, and inflammatory stimuli. Dysregulation of these cells is implicated in skin disorders including psoriasis, eczema, and non-melanoma skin cancers. They serve as valuable in vitro models for studying wound healing, barrier function, and epidermal responses to pharmacological agents. To maintain cell viability, repeated freeze-thaw cycles should be avoided.