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Human Hepatic Stellate Cells

Product Name

Human Hepatic Stellate Cells

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1 vial

Biosafety Level


Shipping Info

Dry Ice


Liquid Nitrogen


Human Hepatic Stellate Cells (HHSC) are primary cells derived from the human liver and cultivated in optimized medium. Positioned between hepatocytes and blood vessels in the liver, they exhibit myofibroblast-like or lipocyte characteristics. HHSC play a crucial role in maintaining liver extracellular matrix homeostasis, contributing to repair, regeneration, fibrosis, and controlling retinol metabolism. Notably, they become activated into fibrogenic myofibroblast-like cells in conditions like chronic alcoholism, hepatitis B and C, fatty liver disease, obesity, and diabetes, leading to liver fibrosis. HHSC are also involved in regulating hepatic microcirculation and can contribute to intrahepatic portal hypertension in disease states. Their proliferation, migration, and chemokine expression are associated with liver inflammation and fibrogenesis.


Why choose Human Hepatic Stellate Cells from AcceGen?

AcceGen’s Human Hepatic Stellate Cells (HHSC) are cryopreserved at passage one and shipped in a frozen state, with each vial containing over 5×105 cells in 1mL. These cells are characterized using immunofluorescence with α-smooth muscle actin-specific antibodies. They are thoroughly tested and confirmed to be negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. Furthermore, these HHSC are guaranteed to expand for up to 15 population doublings when cultured under the conditions provided by AcceGen.



Source Organ


Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).



Human Hepatic Stellate Cells (HHSC) find versatile applications in various cell-based assays, including toxicity assessment, drug screening, and metabolism studies, making them valuable tools for investigating liver function, physiology, and liver diseases. Additionally, gaining a deeper understanding of the molecular mechanisms behind HHSC activation holds the potential to pave the way for innovative therapeutic approaches in treating hepatic fibrosis, offering the promise of reducing morbidity and mortality rates among patients suffering from chronic liver injuries.

Growth Conditions

37 ℃, 5% CO2

Cell Type

Stellate Cell

Growth Mode


Product Type

Hepatic Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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