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Primary Cells

Human Hepatocytes

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The liver fulfills many vital processes in mammals. It is the central organ of energy metabolism, biotransformation of xenobiotics, and synthesis of plasma proteins under physiological and pathophysiological conditions. Primary human hepatocyte culture is an important experimental model for the study of liver specific function. Propagation of human hepatocytes is critical for gene therapy, cell […]
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Product Code

HH

Species

Human

Cat.No

ABC-TC3646

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Hepatocyte

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Liver

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Hepatic Cells

Key Features

-Backed by AcceGen advanced technology

-Ship cryopreserved cells in dry ice

-Quality-tested for accurate results

Description

Human Hepatocytes are isolated from the human liver tissue. Hepatocytes are the main parenchymal cells of the liver, occupying most of the liver’s volume (about 80%). These cells are rich in Golgi apparatus and mitochondria, enabling them to perform essential functions in metabolism, protein synthesis, and detoxification.Studies have shown that in non-alcoholic fatty liver disease (NAFLD), hepatocytes undergo a series of metabolic changes such as the decreased ketone body production and increased glycolysis. In vitro, human hepatocytes display a polygonal morphology, form tight junctions, and exhibit adherent monolayer growth. Hepatocytes also have immune functions and can produce and secrete innate immune proteins such as Complement C3, Lectin MBL, MAp19, MASP1, 2 3, and C-reactive protein (CRP), which can activate innate immunity, directly eliminate pathogens, and coordinate the immune system to fight pathogens

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Citation

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Application

  • Human Hepatocytes can be used to study the mechanism of liver disease. These cells can also be used for safety assessment (such as prediction of liver toxicity) and metabolic kinetics research during the drug development stage, helping to improve the reliability of clinical trials.

Frequently Asked Questions

  • What are Human Hepatocytes, and how are they obtained?

    Human Hepatocytes are the main functional cells of the liver, responsible for various metabolic processes, detoxification, and protein synthesis. They are isolated from donor’s liver tissue through enzymatic digestion and are either freshly isolated or cryopreserved for research use.

  • What are the primary applications of Human Hepatocytes in research?

    Human Hepatocytes are widely used in drug metabolism studies, toxicology testing, liver disease research, pharmacokinetic studies, and tissue engineering. They serve as a critical model for understanding liver function and drug interactions.

  • How do Human Hepatocytes differ from hepatoma cell lines?

    Human Hepatocytes are primary cells with normal liver cell functions, making them more physiologically relevant for certain studies. In contrast, hepatoma cell lines, such as HepG2, are cancer-derived and may not accurately represent normal liver function, particularly in drug metabolism and toxicity studies.

  • Can Human Hepatocytes be passaged in culture?

    No, Human Hepatocytes cannot be passaged in culture like immortalized cell lines. They are primary cells, meaning they have a limited lifespan and do not proliferate in culture. After a few days in culture, hepatocytes will begin to lose their specific liver functions and eventually undergo senescence. For extended studies, it is often necessary to use fresh or cryopreserved hepatocytes for each experiment rather than attempting to passage them.

  • What types of Human Hepatocyte products are available?

    We offer both suspension and Platable Human Hepatocytes in various formats and quantities. Please contact our sales team for detailed information on the specific options available.

Inquiring Human Hepatocytes

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To support a consistent result
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