Human Liver Microsomes-200 Donors (0.5 mL)

Description

Human Liver Microsomes (HLM)-200 Donors (0.5 mL) are pooled, subcellular fractions derived from liver tissues of approximately 200 healthy human donorswith diverse demographics, providing a representative average human metabolic profile. These microsomes are enriched in smooth endoplasmic reticulum vesicles and contain the major drug-metabolizing enzymes, including the major phase-I cytochrome P450 (CYP) families and phase-II enzymes such as UDP-glucuronosyltransferases (UGTs), sulfotransferases (SULTs), and glutathione-S-transferases (GSTs). HLM are widely used in vitro to study xenobiotic biotransformation, specially for assessing intrinsic clearance, enzyme reaction phenotyping, and drug-drug interaction potential. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.