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Human Liver Sinusoidal Endothelial Cells

Product Name

Human Liver Sinusoidal Endothelial Cells

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Product Code

HHSEC

Cat.No

ABC-TC3679

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Endothelial cells play multiple physiological functions and are central to many pathological processes. The liver contains two distinct endothelial cell types: vascular and sinusoidal. Sinusoidal endothelial cells (SEC) are microvascular endothelial cells with a unique phenotype reminiscent of dendritic cells and a unique function as antigen-presenting cells for CD4+ T cells. Thus, SEC represent a new type of organ-resident “non-professional” antigen-presenting cell that appears to be involved in the local control of the immune response and the induction of immune tolerance in the liver. The hepatic microenvironment, i.e. portal venous constituents and soluble mediators from sinusoidal cell populations, tightly control antigen presentation by SEC to avoid immune-mediated damage. SEC express well-characterized surface receptors and differ morphologically and metabolically from large-vessel endothelia. It has reported that SEC are dynamic regulators of porosity that respond rapidly and locally to environmental zonal stimuli during liver regeneration. Due to its strategic position in the liver sinusoid, SEC dysfunction and structural alterations have far-reaching repercussions for the whole liver. HHSEC from AcceGen Research Laboratories are isolated from human liver. HHSEC are cryopreserved immediately after purification and delivered frozen. Each vial contains >5×10^5 cells in 1 ml volume. HHSEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII and CD31 (P-CAM). HHSEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HHSEC are guaranteed to further expand for 15 population doublings in the conditions provided by AcceGen Research Laboratories.

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only

Product Type

Hepatic Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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