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Primary Cells

Human Liver Sinusoidal Endothelial Cells

  • For research use only

Cat No.

ABC-TC3679
Product Type

Hepatic Cells
Cell Type

Endothelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Storage

Liquid Nitrogen

Human Liver Sinusoidal Endothelial Cells are used for liver injury, immune response, fibrosis, and hepatotoxicity studies in hepatic vascular research.

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  • Human Liver Sinusoidal Endothelial Cells
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Liver Sinusoidal Endothelial Cells

Description

Human Liver Sinusoidal Endothelial Cells (HLSECs) (lsec cells) are isolated from human liver tissue. In vitro, these cells exhibit anchorage-dependent growth. They typically display an elongated or spindle-like morphology with fenestrations in their cytoplasm, a hallmark feature of sinusoidal endothelial cells. HLSECs are highly specialized endothelial cells, and they play a crucial role in liver regeneration following acute liver injury. Through a cascade of complex physiological and molecular interactions, HLSECs initiate and support the repair and restoration of liver tissue structure and function. Moreover, HLSECs are involved in the pathogenesis of various liver-related diseases, such as the occurrence and development of hepatocellular carcinoma (HCC). The phenotypic plasticity of HLSECs during liver injury and repair positions them as important therapeutic targets for liver diseases. LSEC cells represent a distinct population of sinusoidal endothelial cells, also referred to as sinusoidal cells, that line the sinusoid capillary network of the liver sinusoid and regulate exchange between blood and hepatic tissue.

Product Code

LSECs
Species

Human
Cat.No

ABC-TC3679
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Hepatic Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Liver Sinusoidal Endothelial Cells, with their unique fenestrated structure and scavenger function, are vital for studying liver physiology, fibrosis, and drug metabolism. They model NAFLD/NASH progression, assess hepatic first-pass effects, and explore immune tolerance. Their role in capillarization and cytokine signaling makes them ideal for disease mechanisms and therapeutic targeting, offering physiologically relevant insights for liver-focused research and preclinical drug development.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are the recommended culture conditions for Human Liver Sinusoidal Endothelial Cells?

    These cells should be cultured in endothelial cell growth medium, supplemented with specialized growth factors.

  • Are these cells cryopreserved, and what is the viability after thawing the cells?

    Yes, they are cryopreserved. Post-thaw viability is typically above 80%, if proper protocols are followed.

  • Can Human Liver Sinusoidal Endothelial Cells be used for drug screening or toxicity studies?

    Yes, these cells are suitable for in vitro drug screening and toxicity studies related to liver function.

  • What is the typical morphology of Human Liver Sinusoidal Endothelial Cells in culture?

    These cells exhibit a typical cobblestone-like morphology of endothelial cells when cultured properly.

  • Do these cells display fenestrations?

    Yes, human liver sinusoidal endothelial cells retain characteristic fenestrations.

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