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Human Liver Sinusoidal Endothelial Cells

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Endothelial cells play multiple physiological functions and are central to many pathological processes. The liver contains two distinct endothelial cell types: vascular and sinusoidal. Sinusoidal endothelial cells (SEC) are microvascular endothelial cells with a unique phenotype reminiscent of dendritic cells and a unique function as antigen-presenting cells for CD4+ T cells. Thus, SEC represent a […]
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Liver Sinusoidal Endothelial Cells
Product Code

LSECs
Species

Human
Cat.No

ABC-TC3679
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Hepatic Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Liver Sinusoidal Endothelial Cells (HLSECs) are isolated from human liver tissue. In vitro, these cells exhibit anchorage-dependent growth. They typically display an elongated or spindle-like morphology with fenestrations in their cytoplasm, which are characteristic of sinusoidal endothelial cells. HLSECs are highly specialized endothelial cells, and they play a crucial role in liver regeneration following acute liver injury. Through a cascade of complex physiological and molecular interactions, HLSECs initiate and support the repair and restoration of liver tissue structure and function. Moreover, HLSECs are involved in the pathogenesis of various liver-related diseases, such as the occurrence and development of hepatocellular carcinoma (HCC). The phenotypic plasticity of HLSECs during liver injury and repair positions them as important therapeutic targets for liver diseases.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human Liver Sinusoidal Endothelial Cells can be used to explore the pathogenesis of liver fibrosis, cirrhosis and liver cancer. These cells can also be used to study the liver immune microenvironment and evaluate the efficiency of drug clearance through the liver.

Frequently Asked Questions

  • What are the recommended culture conditions for Human Liver Sinusoidal Endothelial Cells?

    These cells should be cultured in endothelial cell growth medium, supplemented with specialized growth factors.

  • Are these cells cryopreserved, and what is the viability after thawing the cells?

    Yes, they are cryopreserved. Post-thaw viability is typically above 80%, if proper protocols are followed.

  • Can Human Liver Sinusoidal Endothelial Cells be used for drug screening or toxicity studies?

    Yes, these cells are suitable for in vitro drug screening and toxicity studies related to liver function.

  • What is the typical morphology of Human Liver Sinusoidal Endothelial Cells in culture?

    These cells exhibit a typical cobblestone-like morphology of endothelial cells when cultured properly.

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