Human Non-Parenchymal Cells

Description

Human Non-Parenchymal Cells include hepatic stellate cells, liver progenitor cells, and intrahepatic bile duct epithelial cells. These cells are isolated from human liver tissue, cultured under primary conditions, and cryopreserved after harvesting. They express UEA-1, αSMA, and CD45. Non-parenchymal cells play critical roles in liver regeneration, immune surveillance, and the metabolism of various compounds. Studies have shown that they contribute to hepatic repair by regulating hepatocyte proliferation and extracellular matrix production. Additionally, these cells are involved in drug metabolism and may play a role in drug-induced liver injury (DILI). In vitro, Human Non-Parenchymal Cells display limited proliferative capacity. Repeated freeze-thaw cycles should be avoided to preserve cellular function and viability. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.