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Human Osteoclast Precursor Cells

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The maintenance and repair of bone tissue is primarily attributed to two cell types: osteoblasts which form new bone tissue and osteoclasts which re-absorb bone tissue. Defects in the bone mineralization/bone degradation cycle contribute to a number of bone related diseases such as osteoporosis. Osteoclasts are large, multinucleated cells that play an active role in […]
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Species

Human

Cat.No

ABC-H0014X

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Osteoclast

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Blood Products

Description

Human Osteoclast Precursor CellsHuman Osteoclast Precursor Cells (OCPs) are primary cells derived from the monocyte/macrophage lineage of human peripheral blood, bone marrow, or umbilical cord blood. These cells are precursors to multinucleated osteoclasts and are implicated in bone-resorptive diseases such as osteoporosis, rheumatoid arthritis, and multiple myeloma. Following isolation, they are cryopreserved and typically not passaged due to their limited proliferative capacity. OCPs exhibit monocyte-like morphology. Functionally, OCPs express surface markers including CD14, CD11b, CD115, and RANK, with CD16+ subsets showing heightened osteoclastogenic potential in inflammatory conditions. Their differentiation is RANKL-dependent, making them powerful models for studying bone metabolism disorders.

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Citation

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Application

  • Human Osteoclast Precursor Cells find versatile applications, notably in high-throughput studies targeting osteoporosis, bone resorption, and related diseases. They offer insights into environmental impacts on osteoclast formation and pathogenic derivation, while also enabling exploration of regulators like chemokines and M-CSF influencing osteoclast precursor cell recruitment to bone. Enhanced comprehension of OCPs’ nature, heterogeneity, and recruitment pathways holds promise for targeted therapies addressing osteoclast-specific concerns.

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