Human Osteoclast Precursor Cells (OCPs) are primary cells derived from the monocyte/macrophage lineage of human peripheral blood, bone marrow, or umbilical cord blood. These cells are precursors to multinucleated osteoclasts and are implicated in bone-resorptive diseases such as osteoporosis, rheumatoid arthritis, and multiple myeloma. Following isolation, they are cryopreserved and typically not passaged due to their limited proliferative capacity. OCPs exhibit monocyte-like morphology. Functionally, OCPs express surface markers including CD14, CD11b, CD115, and RANK, with CD16+ subsets showing heightened osteoclastogenic potential in inflammatory conditions. Their differentiation is RANKL-dependent, making them powerful models for studying bone metabolism disorders.
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