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Human Osteoclast Precursor Cells

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The maintenance and repair of bone tissue is primarily attributed to two cell types: osteoblasts which form new bone tissue and osteoclasts which re-absorb bone tissue. Defects in the bone mineralization/bone degradation cycle contribute to a number of bone related diseases such as osteoporosis. Osteoclasts are large, multinucleated cells that play an active role in […]
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Home | Primary Cells | Human Primary Cells | Blood System Primary Cells | Human Osteoclast Precursor Cells
Species

Human
Cat.No

ABC-H0014X
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Osteoclast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Blood Products

Description

The preservation and restoration of bone tissue involve osteoblasts, responsible for bone formation, Human Osteoclast Precursor Cellsand osteoclasts, accountable for bone resorption. Osteoclasts, multinucleated cells that absorb bone, originate from pluripotential hematopoietic stem cells and share precursor cells with the mononuclear phagocyte system. The ligand RANKL, produced by osteoblasts, along with M-CSF, facilitates the development of active osteoclasts when introduced to osteoclast precursor cultures. Retinoic Acid enhances the proliferation of human osteoclast progenitors and hinders RANKL-induced osteoclast differentiation by suppressing the RANK receptor.

 

Why choose Human Osteoclast Precursor Cells from AcceGen?

AcceGen’s Human Osteoclast Precursor Cells are favored for their high yield of up to 50% conversion to osteoclasts during differentiation. These cryopreserved cells assure over 1 million viable cells per ampoule, demonstrating osteoclast activity and TRAP staining post-differentiation. Additionally, they are free from HIV-1, hepatitis B, and hepatitis C, ensuring every cell lot safety.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • FOR RESEARCH USE ONLY

  • Human Osteoclast Precursor Cells find versatile applications, notably in high-throughput studies targeting osteoporosis, bone resorption, and related diseases. They offer insights into environmental impacts on osteoclast formation and pathogenic derivation, while also enabling exploration of regulators like chemokines and M-CSF influencing osteoclast precursor cell recruitment to bone. Enhanced comprehension of OCPs’ nature, heterogeneity, and recruitment pathways holds promise for targeted therapies addressing osteoclast-specific concerns.

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