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Primary Cells

Human Ovarian Surface Epithelial Cells

  • For research use only

Cat No.

ABC-TC3743
Product Type

Female Reproductive Cells
Cell Type

Epithelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Ovarian
Disease

Normal
Storage

Liquid Nitrogen

HOSECs from ovarian surface form cobblestone monolayers, express CK7, E-cadherin, hormone receptors, used for ovarian cancer and EMT research.

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  • Human Ovarian Surface Epithelial Cells
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Home | Primary Cells | Human Primary Cells | Reproductive System Primary Cells | Human Ovarian Surface Epithelial Cells

Description

Human Ovarian Surface Epithelial Cells (HOSECs) are primary cells isolated from the outer layer of healthy human ovaries. In vivo, these cells display diverse morphologies, ranging from squamous to cuboidal to low columnar. HOSECs play a crucial role in ovarian physiology, including ovulation and repair of the ovarian surface following follicle rupture. HOSECs express key markers such as cytokeratin 8/18, E-cadherin, and CA-125. In addition, they express estrogen receptor alpha (ERα) and beta (ERβ), and progesterone receptor (PR), verified by immunostaining. When co-cultured with endometrial stromal cells under estrogen-rich conditions, these cells form gland-like structures. They are also significant in studying ovarian pathologies, as the ovarian surface epithelium is the origin of most epithelial ovarian cancers. These cells provide an ideal in vitro model for researching ovarian cancer initiation, epithelial-mesenchymal transition (EMT), and response to hormonal stimuli.

Product Code

HOSEpiC
Species

Human
Cat.No

ABC-TC3743
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Ovarian
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Female Reproductive Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Ovarian Surface Epithelial Cells serve as a critical in vitro model for investigating the cellular and molecular mechanisms underlying the development of epithelial ovarian carcinoma (EOC), particularly high-grade serous carcinoma. Studies investigating the ovarian surface epithelium (OSE) and its morphological alterations following ovulation, as well as its involvement in the origin of epithelial ovarian carcinomas, are central to understanding ovarian tumorigenesis. Elucidating dysregulated signaling pathways that govern HOSEC survival, apoptosis, proliferation, and epithelial-to-mesenchymal transition (EMT) is of clinical relevance. These insights are critical for characterizing disease progression and for identifying molecular biomarkers that may inform early detection, therapeutic targeting, and personalized management of epithelial ovarian cancer.

Citation

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Frequently Asked Questions

  • What are Human Ovarian Surface Epithelial Cells?

    Human Ovarian Surface Epithelial Cells are the layer of cells that cover the surface of the ovary. They are involved in the ovulation process and are the origin of most ovarian cancers, making them significant in both reproductive biology and cancer research.

  • What functions do Human Ovarian Surface Epithelial Cells perform?

    Human Ovarian Surface Epithelial Cells play a role in protecting the ovary and participate in the ovulation process by covering the ovarian surface. They also undergo cyclic changes in response to hormonal fluctuations and are involved in the repair of the ovarian surface after ovulation.

  • What are the common research applications of Human Ovarian Surface Epithelial Cells?

    These cells are used in research to study ovarian biology, the mechanisms of ovulation, and the pathogenesis of ovarian cancer. They are also important for exploring the effects of hormones on ovarian function and for developing targeted therapies for ovarian cancer.

  • How do Human Ovarian Surface Epithelial Cells relate to ovarian cancer?

    The majority of ovarian cancers are believed to originate from Human Ovarian Surface Epithelial Cells. Studying these cells can provide insights into the early events of ovarian carcinogenesis, helping to identify potential biomarkers and therapeutic targets for ovarian cancer.

  • Can Human Ovarian Surface Epithelial Cells be used in drug screening?

    Yes, Human Ovarian Surface Epithelial Cells can be used in drug screening, particularly for testing the effects of chemotherapeutic agents or targeted therapies on ovarian cells. They provide a relevant model for assessing the response of ovarian tissue to various treatments.

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