Immortalized Human Brain Microvascular Endothelial Cells (IM-HBMEC) are developed by immortalizing primary human brain microvascular endothelial cells (HBMECs) using the SV40 Large T antigen. These cells maintain the immune barrier properties of primary HBMECs. IM-HBMEC cells exhibit a polygonal, cobblestone-like morphology and grow as adherent monolayers. They can undergo more than 30 passages without senescence, unlike primary HBMECs, which undergo early senescence after the 3rd passage.The IM-HBMEC cell line is non-tumorigenic and does not exhibit metastatic behavior. It mimics primary HBMECs in assays such as leukocyte migration, cytokine production, and reactions to astrocyte coculture. Flow cytometry shows no significant differences in immune responses compared to primary HBMECs. The cells express VE-cadherin, ZO-1, and claudin-5, essential for blood-brain barrier integrity.
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