For research use only
| Cat No. | ABC-TC0605 |
| Product Type | Human Colon Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Colon |
| Disease | Colorectal Adenocarinoma |
| Product Code | LS-180; LS 180 |
LS-180,Human colon adenocarcinoma cells used for cancer research, tumorigenicity assays, and studies of CEA, mucin secretion, and drug response.
LS-180 is a human epithelial colorectal adenocarcinoma cell line derived from the colon of a 58-year-old Caucasian female patient with colon adenocarcinoma (Dukes type B adenocarcinoma). It exhibits adherent growth and goblet cell morphology, characterized by abundant mucin secretion. The cell line maintains a stemline karyotype with a notable translocation at t(X;5)(q12;q31) and approximately 2. 2% tetraploid cells. LS-180 cells are microsatellite instability-high (MSI-H) and harbor mutations in ACVR2A and CTNNB1 genes. They express high levels of carcinoembryonic antigen (CEA), making them a valuable model for gastrointestinal research. Additionally, LS-180 cells show elevated expression of Lewis antigens, particularly sialyl Lewis x/a epitopes, correlating with upregulation of glycosyltransferases such as FUT3 and FUT6. These characteristics underscore LS-180’s utility in studying colorectal cancer biology, drug transport mechanisms, and glycan-mediated signaling pathways.
| Product Code | LS-180; LS 180 |
| Species | Human |
| Cat.No | ABC-TC0605 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Colon |
| Disease | Colorectal Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Colon Cancer Cell Lines |
LS-180 cells serve as a robust in vitro model for investigating intestinal drug transport, particularly in studies involving the pregnane X receptor (PXR) and cytochrome P450 enzymes like CYP3A4. They are instrumental in evaluating drug-drug interactions and assessing the induction of multidrug resistance proteins. Furthermore, their high CEA production makes them suitable for cancer biomarker research and therapeutic development.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
