Rat Aortic Smooth Muscle Cells, adult

Description

Rat Aortic Smooth Muscle Cells (RAOSMC) are contractile cells isolated from the tunica and media of healthy, plaque-free rat aortae. These spindle-shaped cells exhibit the classic “hill-and-valley” pattern and express contractile markers such as α-smooth muscle actin, SM-MHC, and calponin, confirming their mature smooth muscle phenotype. RAOSMCs display robust proliferation capacity and phenotypic flexibility, responding to vasoactive agonists like angiotensin II and mechanical stretch by modulating ECM gene expression (e.g., collagen I, fibronectin) and undergoing phenotypic switching. They are ideal for modeling vascular biology—including atherosclerosis, hypertension, and mechanotransduction. Each lot undergoes rigorous screening and isolation procedures and is tested to ensure it is free from contamination by Mycoplasma, Fungi, Yeast, and Bacteria.