For research use only
| Cat No. | ABC-TC484S |
| Product Type | Human Thyroid Cancer Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Thyroid |
| Product Code | MTC-TT |
TT produces calcitonin and peptide hormones, making it a model for investigating medullary thyroid carcinoma biology and peptide-secreting tumors.
The TT cell line is a well-characterized human medullary thyroid carcinoma (MTC) model established from a needle biopsy specimen of a primary tumor in a 77-year-old Caucasian female. This adherent epithelial-like cell line exhibits an aneuploid human karyotype with a modal chromosome number of 40 (range 38-42). TT cells demonstrate neuroendocrine differentiation through constitutive hypersecretion of calcitonin and carcinoembryonic antigen (CEA), along with production of multiple peptide hormones including adrenocorticotropic hormone (ACTH), neurotensin, met-enkephalin, parathyroid hormone-related protein (PTHrP), gastrin-releasing peptide (GRP), and serotonin (5-HT). In vivo, TT cells consistently form subcutaneous tumors within 4-6 weeks when xenografted into immunodeficient mice. These features, combined with retained somatic RET proto-oncogene mutations typical of MTC, make TT cells a clinically relevant model for studying neuroendocrine tumor biology and testing targeted therapies.
| Product Code | MTC-TT |
| Species | Human |
| Cat.No | ABC-TC484S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Thyroid |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Thyroid Cancer Cell Lines |
The TT cell line serves as a valuable tool for studying medullary thyroid carcinoma (MTC), particularly in preclinical investigations aimed at understanding tumor behavior and evaluating novel therapeutics. It plays a crucial role in conducting 3D culture models to better simulate the tumor microenvironment, enabling studies on tumor invasion, migration, proliferation, apoptosis, cell cycle dynamics, and miRNA regulation. TT cells provide a robust platform for evaluating anti-cancer compounds and elucidating molecular mechanisms associated with MTC pathogenesis and treatment resistance, thereby contributing to the development of targeted treatments for this specific malignancy.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
