For research use only
| Cat No. | ABC-TC0032 |
| Product Type | Human Lung Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Disease | Lung Cancer |
| Product Code | A 549; A-549; NCI-A549; hA549 |
A549 cells model alveolar epithelial function and are ideal for evaluating lung carcinoma signaling, epithelial transport, and drug interactions.
The A549 cell line is a well-characterized human lung adenocarcinoma model derived from a 58-year-old Caucasian male patient with alveolar cell carcinoma. These adherent cells display a cobblestone-like morphology typical of epithelial origin and retain features of type II alveolar pneumocytes, including the ability to synthesize lecithin and dipalmitoylphosphatidylcholine (DPPC), and the expression of surfactant proteins. A549 cells are tumorigenic in nude mice and possess a mutated KRAS (G12S) oncogene and wild-type TP53, making them particularly useful for studying RAS-driven oncogenic signaling and chemoresistance mechanisms. They also harbor KEAP1/NRF2 pathway mutations enhancing oxidative stress resistance. This line is widely employed in toxicology, drug screening, and pulmonary research due to their reproducible growth in standard culture conditions (DMEM/F12 medium).
| Product Code | A 549; A-549; NCI-A549; hA549 |
| Species | Human |
| Cat.No | ABC-TC0032 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Disease | Lung Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
The A549 cell line is widely used in drug development for both in vitro assays and in vivo xenograft lung cancer models. It facilitates enzymatic studies on cancer cell proliferation and insulin-mediated effects, supporting evaluation of novel therapeutic agents.
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