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| Product Code | A 549; A-549; NCI-A549; hA549 |
| Species | Human |
| Cat.No | ABC-TC0032 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Disease | Lung Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
The A549 cell line was established in 1972 from the lung adenocarcinoma of a 58-year-old Caucasian male. These hypotriploid alveolar basal epithelial cells have a modal chromosome number of 66, with occasional variations. A549 cells express keratin, synthesize lecithin, and contain unsaturated fatty acids. They are squamous and play a role in the diffusion of substances across the lung’s alveolar space. Genetically, A549 cells exhibit mutations in TP53, KRAS, and STK11, commonly associated with lung adenocarcinoma. The A549 cell line is tumorigenic, with low metastatic behavior reported in some studies. No viral infections like HPV, HIV, or EBV have been reported.
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In drug development, the A549 cell line can be utilized for in vitro and in vivo testing of novel drugs, including xenograft lung cancer models. Furthermore, A549 cells can also be used in enzymatic studies to investigate cancer cell proliferation and the effects of insulin.
