For research use only
| Cat No. | ABC-TC1234 |
| Product Type | Human Leukemia Cell Lines |
| Cell Type | Monocyte |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Blood |
| Disease | Acute Myeloid Leukemia |
| Product Code | THP1; THP 1; THPI |
THP-1 Monocytic Cells are phagocytic and support monocytic differentiation, inflammation pathway analysis, and immune cell response modeling.
THP-1 is a human monocytic leukemia cell line established from the peripheral blood of a 1-year-old Caucasian male diagnosed with acute monocytic leukemia (AML-M5, FAB classification). The cells grow in suspension with a round morphology and exhibit phenotypic and functional characteristics typical of monocytes. THP-1 cells express surface Fc and C3b receptors but lack both surface and cytoplasmic immunoglobulins. They display positive α-naphthyl butyrate esterase activity that is NaF-sensitive—an enzymatic marker of monocytic lineage—and are capable of phagocytosing latex beads and opsonized sheep red blood cells. Functionally, THP-1 cells secrete lysozyme and can restore Concanavalin A-induced T lymphocyte responses, further supporting their monocyte-like phenotype. This cell line expresses the HLA haplotypes HLA-A2, -A9, -B5, -DRW1, and -DRW2. Cytogenetically, THP-1 exhibits a near-diploid karyotype with multiple structural aberrations, consistent with leukemic transformation. In xenograft models, THP-1 cells demonstrate tumorigenic potential but lack metastatic capacity. THP-1 is widely utilized in immunological research, particularly in studies of the NLRP3 inflammasome, NF-κB signaling, and innate immune responses.
| Product Code | THP1; THP 1; THPI |
| Species | Human |
| Cat.No | ABC-TC1234 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Monocyte |
| Growth Mode | Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Blood |
| Disease | Acute Myeloid Leukemia |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
THP-1 cells find diverse applications due to their unique characteristics. They are widely used for transfection, enabling gene manipulation and functional studies. Additionally, these cells offer valuable insights into monocyte biology and immune responses, providing a reliable model to study monocyte-to-macrophage differentiation. Moreover, THP-1 cells prove invaluable in assessing immune-modulatory effects of compounds in both resting and activated states, making them essential in drug development and immunological research.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
THP-1 cells are a human monocytic leukemia cell line. They are widely used in immunology research as a model for monocyte and macrophage function, including studies of inflammation, cytokine production, and pathogen response.
