Rationally targeted anti-VISTA antibody that blockades the C-C’ loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner

Date Published: 22-Aug-22

Authors: Dipti Thakkar, Shalini Paliwal, Bhushan Dharmadhikari, Siyu Guan,1 Lillian Liu, Shreya Kar,1 Nikhil K Tulsian, Joshua J Gruber, Leah DiMascio, Konrad H Paszkiewicz, Piers J Ingram, and Jerome D Boyd-Kirkup
Journal: Journal for Immuno Therapy of Cancer
DOI: 10.1136/jitc-2021-003382
Cited AcceGen Product/Service: PBMCs

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Home > Publications >Rationally targeted anti-VISTA antibody that blockades the C-C’ loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner >

Rationally targeted anti-VISTA antibody that blockades the C-C’ loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner