Human Fallopian Tube Epithelial Cells

Description

Human Fallopian Tube Epithelial Cells (FTECs) are primary cells derived from the mucosal epithelium of human fallopian tubes, predominantly isolated from the distal fimbrial region of healthy adult donors. These cells include distinct polarized epithelial subtypes such as ciliated cells and secretory cells, along with minor populations of intercalary and undifferentiated cells. These cells are typically cryopreserved at early passages to maintain their native characteristics and cannot be serially passaged in vitro. Functionally, hFTECs are integral to gamete transport, secrete antimicrobial factors, and immune surveillance, in part via Toll-like receptor 3 (TLR3)-mediated responses. Importantly, FTECs – particularly secretory cells – are implicated in the pathogenesis of high-grade serous ovarian carcinoma (HGSOC), making them a focal point in cancer research. These cells express epithelial markers such as cytokeratin-17 (CK-17) and PAX8. Their dual role in bothreproductive physiology and carcinogenesis make them a powerful model for studying HGSOC progression, tubal microenvironment and epithelial transformation.