C6

The C6 cell line, originating from a Wistar-Furth rat glioma induced by N-nitrosomethylurea exposure, maintains a glial cell phenotype characterized by fibroblast-like morphology. Genetically heterogeneous, these cells exhibit a wild-type p53 gene, elevated Rb gene expression, and a mutant p16/Cdkn2a/Ink4a locus with concomitant absence of p16 and p19ARF mRNA expression. Notably, C6 cells overexpress key genes implicated in human gliomas, including PDGF, IGF-1, EGFR, and Erb3/Her3 precursor proteins. Mirroring human gliomas, C6 cells manifest increased Ras pathway gene activity, under the regulatory influence of elevated Ras guanine triphosphate activator protein expression.

Why choose C6 from AcceGen?

C6 cells from AcceGen are characterized by their exceptional viability and quality, as they are meticulously incubated under optimal conditions and subject to daily monitoring for the absence of bacteria and fungi. Furthermore, a rigorous PCR-based assay is employed to verify the absence of mycoplasma contamination, and the cell line’s identity is confirmed through STR analysis, ensuring the reliability and integrity of these cells for various research applications.