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Primary Cells

Human Colorectal Tumor Carcinoma Associated Fibroblasts

  • For research use only

Cat No.

ABC-TC5537
Product Type

Human Primary Carcinoma Associated Fibroblasts
Cell Type

Fibroblast
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Colorectal
Disease

Colorectal Tumor Carcinoma
Storage

Liquid Nitrogen

Human Colorectal Tumor Carcinoma Associated Fibroblasts are CAFs influencing epithelial tumor growth, metastasis, and treatment response in cancer models.

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  • Human Colorectal Tumor Carcinoma Associated Fibroblasts
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Colorectal Tumor Carcinoma Associated Fibroblasts

Description

Human Colorectal Tumor Carcinoma-Associated Fibroblasts (CAFs) are primary mesenchymal cells isolated from the stromal compartment of human colorectal carcinoma tissue. These fibroblasts exhibit a spindle-shaped morphology and strong adherent growth in vitro. CAFs actively remodel the extracellular matrix (ECM) and secrete a range of tumor-promoting factors, including hepatocyte growth factor (HGF), interleukin-6 (IL-6), and matrix metalloproteinases (MMPs), contributing to tumor progression, angiogenesis, and chemoresistance. Immunophenotypically, they express markers such as α-smooth muscle actin (α-SMA), fibroblast activation protein (FAP), and vimentin. These CAFs significantly enhance tumorigenicity when co-implanted with colorectal cancer cells, accurately mimicking the human tumor microenvironment. This cell model is a physiologically relevant tool for investigating tumor–stroma crosstalk and identifying therapeutic targets in colorectal cancer.

Product Code

Human Colorectal Tumor Carcinoma Associated Fibroblasts, hCRC-CAFs, Human Colorectal CAFs, Human Colorectal Tumor Carcinoma Associated Fibroblasts
Species

Human
Cat.No

ABC-TC5537
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Colorectal
Disease

Colorectal Tumor Carcinoma
Storage

Liquid Nitrogen
Product Type

Human Primary Carcinoma Associated Fibroblasts

Application

  • Human Colorectal Tumor Carcinoma-Associated Fibroblasts (CAFs) allow researchers to develop 3D interpenetrating network hydrogel culture systems that enable precise modulation of the tumor microenvironment’s mechanical properties. This innovative platform allows in-depth study of CAF phenotype transitions and their dynamic interactions with colorectal cancer cells. By manipulating the mechanical characteristics of the microenvironment, the system revealed specific conditions linked to patient survival outcomes, providing novel insights that could inform the development of future therapeutic strategies against colorectal cancer.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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