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Human Renal Mesangial Cells

Product Name

Human Renal Mesangial Cells

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Product Code

HRMC

Cat.No

ABC-TC3784

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Renal mesangial cells (RMC) are perivascular pericytes located within the central portion of the glomerular tuft between capillary loops. Mesangial cells have a variety of functions including synthesis and assembly of the mesangial matrix, endocytosis and processing of plasma macromolecules, and control of glomerular hemodynamics via mesangial cell contraction or release of vasoactive hormones. Mesangial cell proliferation and matrix overproduction are the predominant pathological features of many forms of glomerulonephritis, such as IgA nephropathy, lupus nephropathy, and diabetic nephropathy and frequently precedes the increase of extracellular matrix in the mesangium and the development of glomerulosclerosis. As proliferation and matrix synthesis/degradation in vitro are regulated by cytokines and growth factors, cultured cells are an ideal tool for studying pathophysiological events such as mesangial expansion, scarring, and glomerulosclerosis.HRMC from AcceGen Research Laboratories are isolated from human renal tissue. HRMC are cryopreserved after purification and delivered frozen. Each vial contains >5×10^5 cells in 1 ml volume. HRMC are characterized by immunofluorescent method with antibodies to fibronectin, Thy-1, and smooth muscle actin. HRMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HRMC are guaranteed to further expand for 15 population doublings at the conditions specified by AcceGen Research Laboratories.

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only

Product Type

Renal Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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