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Primary Cells

Human Renal Mesangial Cells

  • For research use only

Cat No.

ABC-TC3784
Product Type

Renal Cells
Cell Type

Mesangial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Storage

Liquid Nitrogen

HRMCs are human renal pericytes regulating glomerular function, remodeling ECM, linked to IgA nephropathy and lupus, cryopreserved with limited growth.

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  • Human Renal Mesangial Cells
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Description

Human Renal Mesangial Cells (HRMCs) are primary cells isolated from the glomerular tissue of healthy human donors and cryopreserved at early passages to preserve their physiological phenotype. These adherent cells display epithelial-like morphology and limited proliferative capacity, with sensitivity to repeated freeze-thaw cycles. Functionally, HRMCs are specialized glomerular pericytes that regulate glomerular capillary flow via contractile activity and contribute to filtration homeostasis by phagocytosing macromolecular debris. They actively produce and remodel the mesangial extracellular matrix (ECM), a process critically involved in the pathogenesis of IgA nephropathy, diabetic nephropathy, and lupus nephritis. HRMCs characteristically express α-smooth muscle actin (α-SMA), fibronectin, and Thy-1, consistent with their contractile and pericytic phenotype. Due to these properties, HRMCs serve as a valuable in vitro model for studying glomerular diseases, ECM remodeling, and drug-induced nephrotoxicity.

Product Code

HRMC
Species

Human
Cat.No

ABC-TC3784
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Mesangial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Renal Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Renal Mesangial Cells (HRMC) serve as an invaluable model for studying glomerular physiology and pathology, particularly mesangial cell injury and matrix remodeling. These cells are instrumental in establishing in vitro disease models for chronic kidney diseases such as diabetic nephropathy and autoimmune glomerulonephritides, supporting investigations into inflammatory signaling, fibrogenic pathways, and glomerular filtration barrier integrity. HRMCs are also suitable for high-throughput and high-content screening (HTS/HCS) platforms, thus making them ideal for drug discovery, biomaterial testing, and toxicity assessment in renal research. Their physiological relevance and disease specific responses make HRMCs a valuable tool for advancing therapeutic strategies aimed at treating glomerular disorders.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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