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NOMO-1

Product Name

NOMO-1

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Product Code

Nomo-1; NOMO1

Cat.No

ABC-TC1314

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

A human monocytic leukemia cell line, NOMO-1, was established from a female with acute monocytic leukemia (M5a). NOMO-1 exhibits promonocytic characteristics, and its differentiation into macrophage-like cells was induced by using 12-o-tetradecanoyl phorbol-13-acetate (TPA). Following the addition of TPA, fibronectin was observed in NOMO-1 cells, and the culture medium showed increased levels of Interleukin-1 (IL-1) α and IL-1 β. TPA also stimulated the secretion of tissue factors from NOMO-1 cells. TPA enhanced the secretion of tissue factor from NOMO-1 cells, while warfarin (1ng/ml) inhibited the secretion. Moreover, the activity of the plasminogen activator (PA) gradually increased during the 17-day culture period. NOMO-1 can be cultured in RPMI1640 medium with 10% FBS.

 

Why choose NOMO-1 from AcceGen?

NOMO-1, our cell product, underwent various tests and analyses to ensure its quality. We evaluated NOMO-1’s cell morphology and cell viability. Its growth performance was tested under culture conditions without antibiotics and antimycotics. Furthermore, we tested NOMO-1 for the absence of HIV-1, HIV-2, HBV, HCV, HTLV-1, and HTLV-2, as well as microbial contaminants such as fungi, bacteria, and mycoplasma. These rigorous assessments confirm the reliability and safety of NOMO-1 as a cell line for various applications.

Disease

Acute Monocytic Leukemia

Source Organ

Peripheral Blood

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

FOR RESEARCH USE ONLY

NOMO-1 is a useful tool to study the differentiation and maturation of monocytes and identify AML-specific antigens for therapeutic targeting. NOMO-1, utilized as a model, exhibits aberrant expression of NANOG, an NKL homeobox gene that functions as a stem cell factor and is specifically expressed in hematopoietic progenitor cells.

NOMO-1 is also employed in drug development and investigating potential signaling pathways. It expresses granulocyte colony-stimulating factor (G-CSF) and responds to exogenous G-CSF. In the NOMO-1 model, it has been observed that exogenous G-CSF increases sensitivity to DNA topoisomerase II-targeting drugs and upregulates the expression of transferrin receptor (TfR). Additionally, NOMO-1 serves as a valuable model for studying drug resistance. It has been confirmed to be resistant to pinometostat (EPZ-5676), a selective inhibitor of DOT1L.

Growth Conditions

37 ℃, 5% CO2

Product Type

Human Leukemia Cell Lines

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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